Impaired mismatch negativity to frequency deviants in individuals at ultra-high risk for psychosis, and preliminary evidence for further impairment with transition to psychosis

S Lavoie; BN Jack; O Griffiths; A Ando; P Amminger; A Couroupis; A Jago; C Markulev; PD McGorry; B Nelson; A Polari; HP Yuen; TJ Whitford

Journal article

Impaired mismatch negativity to frequency deviants in individuals at ultra-high risk for psychosis, and preliminary evidence for further impairment with transition to psychosis

S Lavoie, BN Jack, O Griffiths, A Ando, P Amminger, A Couroupis, A Jago, C Markulev, PD McGorry, B Nelson, A Polari, HP Yuen, TJ Whitford

Schizophrenia Research | ELSEVIER SCIENCE BV | Published : 2018

DOI: 10.1016/j.schres.2017.11.005

Abstract

Background There is evidence to suggest that people with established psychotic disorders show impairments in the mismatch negativity induced by a frequency-deviant sound (fMMN), and that these impairments worsen with the deterioration of psychotic symptoms. This study aimed to test whether individuals at ultra-high risk (UHR) for psychosis show pre-morbid impairments in fMMN, and if so, whether fMMN continues to deteriorate with transition to psychosis. Method fMMN was recorded in a cohort of UHR individuals (n = 42) and compared to healthy controls (n = 29). Of the 27 UHR participants who returned for a second EEG session, six participants had transitioned to psychosis by 12-month follow-up..

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University of Melbourne Researchers

Suzie Lavoie Author

Paul Amminger Author

Connie Markulev Author

Patrick McGorry Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

This work was supported by a grant from the University of Melbourne (601947) (SL) and a NARSAD grant (17537; TW). The Neurapro study was supported by the Stanley Medical Research Institute (07TGF-1102), the NHMRC Australia Program (566529) and the Colonial Foundation. BN was supported by a NARSAD Independent Investigator Grant from the Brain & Behavior Research Foundation (23199), OG was supported by an Australian Research Council (ARC) grant (DE150100667), and TW is supported by a Career Development Fellowship from the NHMRC1 (APP1090507) and Discovery Projects from the ARC (DP140104394; DP170103094).